In vitro Antioxidant and Acidic Properties of Novel 4-(5-Methyl-2-thienyhnethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives. Synthesis and Characterization

Kol O. G., Yuksek H., İSLAMOĞLU F.

REVISTA DE CHIMIE, vol.63, no.11, pp.1103-1111, 2012 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 11
  • Publication Date: 2012
  • Journal Name: REVISTA DE CHIMIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1103-1111
  • Recep Tayyip Erdoğan University Affiliated: Yes


In the present study 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2a-i reacted with 5-methyl-thiophene-2-carboxyaldehyde to afford the corresponding compounds 3a-i and the acetylation reactions of compounds 3a, 3b, 3d, 3g and 3i were investigated. The structures of fourteen new compounds are established from the spectral data. The synthesized 3 and 4 type compounds were analyzed for their in vitro potential antioxidant activities by three different methods. Besides, compounds 3a-i were titrated potentiometrically with tetrabutylammonium hydroxide in four nonaqueous solvents.