In vitro Antioxidant and Acidic Properties of Novel 4-(5-Methyl-2-thienyhnethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives. Synthesis and Characterization

Kol O. G. , Yuksek H., İSLAMOĞLU F.

REVISTA DE CHIMIE, cilt.63, sa.11, ss.1103-1111, 2012 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Konu: 11
  • Basım Tarihi: 2012
  • Sayfa Sayıları: ss.1103-1111


In the present study 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2a-i reacted with 5-methyl-thiophene-2-carboxyaldehyde to afford the corresponding compounds 3a-i and the acetylation reactions of compounds 3a, 3b, 3d, 3g and 3i were investigated. The structures of fourteen new compounds are established from the spectral data. The synthesized 3 and 4 type compounds were analyzed for their in vitro potential antioxidant activities by three different methods. Besides, compounds 3a-i were titrated potentiometrically with tetrabutylammonium hydroxide in four nonaqueous solvents.