Akademik Veri Yönetim Sistemi
6TH INTERNATIONAL BLACK SEA MODERN SCIENTIFIC RESEARCH CONGRESS, Trabzon, Türkiye, 23 - 25 Ağustos 2024, ss.171-176, (Tam Metin Bildiri)
Rhododendron species are medicinal plants with highly effective biological properties due to a large
number of secondary metabolites such as flavonoids, saponins, tannins, steroids, and alkaloids. The
present study aimed to determine the phytochemical contents of ethanolic extracts of R. luteum
flowers with HPLC-DAD. In addition, the possible inhibition of enzymes such as urease and α-
glucosidase by R. luteum extracts was determined by in vitro experiments. R. luteum flowers were
collected and freshly extracted with ethanol. HPLC-DAD gradient elution was used to elucidate the
phenolic content of the flower extracts. Urease enzyme inhibition, which is important in the
treatment of gastrointestinal disorders, and glucosidase inhibition, which plays a role in the
treatment of diabetes mellitus, were investigated in the extracts obtained. The flower of R. luteum
was analyzed by HPLC-DAD and found to be very rich in phenolic compounds such as gallic acid,
caffeic acid, protocatechuic acid, ferulic acid, vanillic acid, chlorogenic acid, and quercetin. In
addition, IC50 values indicating urease and glucosidase inhibition activities of the flower extract
were found to be 30.5 and 180.9 μg.ml-1, respectively. The results of this study showed that R.
luteum flower, with its rich phenolic content and enzyme inhibition ability, can be used as a food
additive and as an active ingredient candidate in pharmacology. The present results may be
supported by additional biological activities and in vivo experiments, such as anticancer and
antibacterial effects.