Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation Studies of Indole-Azole-Fluoroquinolone and Indole-Azole Hybrids

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Uygun Cebecia Y., Basoglu Özdemir S., Demirbas A., Demirbas N., ALPAY KARAOĞLU Ş.

PROBE CHEMİSTRY, vol.1, no.1, pp.1-14, 2018 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 1 Issue: 1
  • Publication Date: 2018
  • Journal Name: PROBE CHEMİSTRY
  • Journal Indexes: Other Indexes
  • Page Numbers: pp.1-14
  • Recep Tayyip Erdoğan University Affiliated: Yes


Abstract: Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-components procedure. Conventional and microwave-assisted methods were applied for all syntheses. All the newly synthesized compounds were screened for their antibacterial and most of them were found to have good–moderate antibacterial activity