Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation Studies of Indole-Azole-Fluoroquinolone and Indole-Azole Hybrids
PROBE CHEMİSTRY, vol.1, no.1, pp.1-14, 2018 (Peer-Reviewed Journal)
- Publication Type: Article / Article
- Volume: 1 Issue: 1
- Publication Date: 2018
- Journal Name: PROBE CHEMİSTRY
- Journal Indexes: Other Indexes
- Page Numbers: pp.1-14
- Recep Tayyip Erdoğan University Affiliated: Yes
Abstract
Abstract: Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-components procedure. Conventional and microwave-assisted methods were applied for all syntheses. All the newly synthesized compounds were screened for their antibacterial and most of them were found to have good–moderate antibacterial activity