Radiotherapy Outcomes and Prognostic Factors in Patients with Soft Tissue Sarcoma
Rize Medical Journal, cilt.1, sa.1, ss.19-28, 2025 (Hakemli Dergi)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 1 Sayı: 1
- Basım Tarihi: 2025
- Dergi Adı: Rize Medical Journal
- Sayfa Sayıları: ss.19-28
- Recep Tayyip Erdoğan Üniversitesi Adresli: Evet
Özet
Abstract Objective: Soft tissue sarcomas are a rare type of cancer that arise from the soft tissues of the body. Treatment outcomes and prognostic factors in 86 patients with soft tissue sarcoma treated with postoperative or primary radiotherapy were retrospectively evaluated for prognosis assessment. Materials and Methods: Patients with soft tissue sarcoma who received postoperative or primary RT were retrospectively evaluated. Parameters such as stage, location, histopathological type, tumor size, surgical features, chemotherapy status and radiotherapy dose/fractionation were evaluated in terms of prognostic value of the disease. Results: The median age of the patients was 45 years (range, 18-80). The median dose of radiotherapy was 60 (range, 40-70) Gy at 1.8-2 Gy/fraction. The median followup period was 53 (range, 3-246 months) months. Five-year OS, DFS and LC were 68%, 61% and 76%, respectively. In univariate analysis, tumor size >10 cm (p=0.01), deep location (p=0.001), grade III-IV (p=0.0001), stage III (p=0.02) and (+) surgical margin (p=0.002) for OS, grade III-IV (p=0.0001), stage III (p=0. 030) and (+) surgical margin (p=0.012); for local control, tumor localization (extremity vs other) (p=0.028), grade III-IV (p=0.004), depth (p=0.035) and (+) surgical margin (p<0.0001) were found to be significant prognostic factors. In multivariate analysis, grade III-IV for OS and DFS (p=0.004 and p=0.001, respectively), surgical margin for local control (p=0.0001) and tumor localization (p=0.06), although not statistically significant, were found to be predictive prognostic factors. Conclusion: In our study; high grade, positive surgical margins and tumor location outside the extremity were found to be the most important prognostic factors. These results are consistent with previous studies and should be taken into consideration in treatment planning. Keywords: Grade, local control, prognostic factor, radiotherapy, soft tissue sarcoma.