Association between rs11362 polymorphism in the beta-defensin 1 (DEFB1) gene and dental caries: A meta-analysis

Hatipoglu O., SAYDAM F.

JOURNAL OF ORAL BIOSCIENCES, vol.62, no.3, pp.272-279, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.1016/j.job.2020.06.004
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.272-279
  • Keywords: Caries susceptibility, Dental caries resistance, Human genome, Single nucleotide polymorphism, Meta-analysis, ANTIMICROBIAL PEPTIDES, CLEFT-LIP, SUSCEPTIBILITY, EXPERIENCE, EXPRESSION, CHILDREN
  • Recep Tayyip Erdoğan University Affiliated: Yes


Objectives: Beta-defensin 1, encoded by the DEFB1 gene, is an important molecule that confers protection from dental caries. Numerous studies have been conducted on the rs11362 polymorphism in the DEFB1 gene. We evaluated the results from studies that have investigated the association between rs11362 polymorphism and dental caries, through a meta-analysis.