Association between rs11362 polymorphism in the beta-defensin 1 (DEFB1) gene and dental caries: A meta-analysis

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Hatipoglu Ö., SAYDAM F.

JOURNAL OF ORAL BIOSCIENCES, vol.62, no.3, pp.272-279, 2020 (ESCI)

• Publication Type: Article / Article
• Volume: 62 Issue: 3
• Publication Date: 2020
• Doi Number: 10.1016/j.job.2020.06.004
• Journal Name: JOURNAL OF ORAL BIOSCIENCES
• Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
• Page Numbers: pp.272-279
• Keywords: Caries susceptibility, Dental caries resistance, Human genome, Single nucleotide polymorphism, Meta-analysis, ANTIMICROBIAL PEPTIDES, CLEFT-LIP, SUSCEPTIBILITY, EXPERIENCE, EXPRESSION, CHILDREN
• Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Objectives: Beta-defensin 1, encoded by the DEFB1 gene, is an important molecule that confers protection from dental caries. Numerous studies have been conducted on the rs11362 polymorphism in the DEFB1 gene. We evaluated the results from studies that have investigated the association between rs11362 polymorphism and dental caries, through a meta-analysis.