The effect of combined hyperbaric oxygen and iloprost treatment on the prevention of spinal cord ischaemia-reperfusion injury: an experimental study

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Ilhan G., AKSUN M., OZPAK B., GUNES T., Bozok S., Durakoglugil M. E., ...Daha Fazla

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, cilt.44, sa.5, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1093/ejcts/ezt398
  • Dergi Adı: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Spinal cord, Ischaemia-reperfusion injury, Hyperbaric oxygen, Iloprost, ANTIOXIDANT ENZYMES, BRAIN, THERAPY
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Hyperbaric oxygen (HBO) has been shown to be effective in preventing neurological injuries in animal models of ischaemia, whereas iloprost (IL) prevents ischaemia-related mitochondrial dysfunction and reduces infarction size after focal cerebral ischaemia in animal models. The aim of the present study was to investigate the effect of combined HBO and IL treatment on spinal cord ischaemia-reperfusion (IR) injury by neurological, histopathological and biochemical methods in an experimental study.