The effect of combined hyperbaric oxygen and iloprost treatment on the prevention of spinal cord ischaemia-reperfusion injury: an experimental study

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Ilhan G., AKSUN M., OZPAK B., GUNES T., Bozok S., Durakoglugil M. E., ...More

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, vol.44, no.5, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.1093/ejcts/ezt398
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Spinal cord, Ischaemia-reperfusion injury, Hyperbaric oxygen, Iloprost, ANTIOXIDANT ENZYMES, BRAIN, THERAPY
  • Recep Tayyip Erdoğan University Affiliated: Yes


Hyperbaric oxygen (HBO) has been shown to be effective in preventing neurological injuries in animal models of ischaemia, whereas iloprost (IL) prevents ischaemia-related mitochondrial dysfunction and reduces infarction size after focal cerebral ischaemia in animal models. The aim of the present study was to investigate the effect of combined HBO and IL treatment on spinal cord ischaemia-reperfusion (IR) injury by neurological, histopathological and biochemical methods in an experimental study.