ARCHIVOS DE BRONCONEUMOLOGIA, vol.51, no.11, pp.551-557, 2015 (SCI-Expanded)
Article / Article
ARCHIVOS DE BRONCONEUMOLOGIA
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Pulmonary toxicity, Methotrexate, Infliximab, Tumor necrosis factor alpha, Endothelin-1, PULMONARY-FIBROSIS, OXIDATIVE STRESS, EPITHELIAL-CELLS, CROHNS-DISEASE, ENDOTHELIN-1, EXPRESSION, APOPTOSIS, TOXICITY, MODEL, OXIDE
Recep Tayyip Erdoğan University Affiliated:
Introduction: Methotrexate (MTX) is used to treat cancers, several forms of arthritis and other rheumatic conditions, although MIX may cause pulmonary toxicity related to the production of free oxygen radicals, various cytokines. Infliximab (IB) with its potent effect on tumor necrosis factor-alpha (TNF-alpha) inhibition also inhibits the release of endothelin-1 (ET-1). We aimed to investigate whether IB reduces pulmonary damage induced by an overdose of MIX.