Protective Effects of Infliximab on Lung Injury Induced by Methotrexate

Kurt A., TUMKAYA L. , Turut H. , CURE M. C. , CURE E., Kalkan Y., ...More

ARCHIVOS DE BRONCONEUMOLOGIA, vol.51, no.11, pp.551-557, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 11
  • Publication Date: 2015
  • Doi Number: 10.1016/j.arbres.2015.03.018
  • Page Numbers: pp.551-557
  • Keywords: Pulmonary toxicity, Methotrexate, Infliximab, Tumor necrosis factor alpha, Endothelin-1, PULMONARY-FIBROSIS, OXIDATIVE STRESS, EPITHELIAL-CELLS, CROHNS-DISEASE, ENDOTHELIN-1, EXPRESSION, APOPTOSIS, TOXICITY, MODEL, OXIDE


Introduction: Methotrexate (MTX) is used to treat cancers, several forms of arthritis and other rheumatic conditions, although MIX may cause pulmonary toxicity related to the production of free oxygen radicals, various cytokines. Infliximab (IB) with its potent effect on tumor necrosis factor-alpha (TNF-alpha) inhibition also inhibits the release of endothelin-1 (ET-1). We aimed to investigate whether IB reduces pulmonary damage induced by an overdose of MIX.