Copy For Citation
Kurt A., TUMKAYA L., Turut H., CURE M. C., CURE E., Kalkan Y., ...More
ARCHIVOS DE BRONCONEUMOLOGIA, vol.51, no.11, pp.551-557, 2015 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
51
Issue:
11
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Publication Date:
2015
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Doi Number:
10.1016/j.arbres.2015.03.018
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Journal Name:
ARCHIVOS DE BRONCONEUMOLOGIA
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.551-557
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Keywords:
Pulmonary toxicity, Methotrexate, Infliximab, Tumor necrosis factor alpha, Endothelin-1, PULMONARY-FIBROSIS, OXIDATIVE STRESS, EPITHELIAL-CELLS, CROHNS-DISEASE, ENDOTHELIN-1, EXPRESSION, APOPTOSIS, TOXICITY, MODEL, OXIDE
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Recep Tayyip Erdoğan University Affiliated:
Yes
Abstract
Introduction: Methotrexate (MTX) is used to treat cancers, several forms of arthritis and other rheumatic conditions, although MIX may cause pulmonary toxicity related to the production of free oxygen radicals, various cytokines. Infliximab (IB) with its potent effect on tumor necrosis factor-alpha (TNF-alpha) inhibition also inhibits the release of endothelin-1 (ET-1). We aimed to investigate whether IB reduces pulmonary damage induced by an overdose of MIX.