Protective Effects of Infliximab on Lung Injury Induced by Methotrexate


Kurt A., TUMKAYA L. , Turut H. , CURE M. C. , CURE E., Kalkan Y., ...More

ARCHIVOS DE BRONCONEUMOLOGIA, vol.51, no.11, pp.551-557, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 11
  • Publication Date: 2015
  • Doi Number: 10.1016/j.arbres.2015.03.018
  • Title of Journal : ARCHIVOS DE BRONCONEUMOLOGIA
  • Page Numbers: pp.551-557

Abstract

Introduction: Methotrexate (MTX) is used to treat cancers, several forms of arthritis and other rheumatic conditions, although MIX may cause pulmonary toxicity related to the production of free oxygen radicals, various cytokines. Infliximab (IB) with its potent effect on tumor necrosis factor-alpha (TNF-alpha) inhibition also inhibits the release of endothelin-1 (ET-1). We aimed to investigate whether IB reduces pulmonary damage induced by an overdose of MIX.