Protective Effects of Infliximab on Lung Injury Induced by Methotrexate

Kurt A., TUMKAYA L., Turut H., CURE M. C., CURE E., Kalkan Y., ...Daha Fazla

ARCHIVOS DE BRONCONEUMOLOGIA, cilt.51, sa.11, ss.551-557, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 11
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.arbres.2015.03.018
  • Dergi Adı: ARCHIVOS DE BRONCONEUMOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.551-557
  • Anahtar Kelimeler: Pulmonary toxicity, Methotrexate, Infliximab, Tumor necrosis factor alpha, Endothelin-1, PULMONARY-FIBROSIS, OXIDATIVE STRESS, EPITHELIAL-CELLS, CROHNS-DISEASE, ENDOTHELIN-1, EXPRESSION, APOPTOSIS, TOXICITY, MODEL, OXIDE
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Introduction: Methotrexate (MTX) is used to treat cancers, several forms of arthritis and other rheumatic conditions, although MIX may cause pulmonary toxicity related to the production of free oxygen radicals, various cytokines. Infliximab (IB) with its potent effect on tumor necrosis factor-alpha (TNF-alpha) inhibition also inhibits the release of endothelin-1 (ET-1). We aimed to investigate whether IB reduces pulmonary damage induced by an overdose of MIX.