ARCHIVOS DE BRONCONEUMOLOGIA, vol.51, no.11, pp.551-557, 2015 (Journal Indexed in SCI)
Article / Article
Title of Journal :
ARCHIVOS DE BRONCONEUMOLOGIA
Pulmonary toxicity, Methotrexate, Infliximab, Tumor necrosis factor alpha, Endothelin-1, PULMONARY-FIBROSIS, OXIDATIVE STRESS, EPITHELIAL-CELLS, CROHNS-DISEASE, ENDOTHELIN-1, EXPRESSION, APOPTOSIS, TOXICITY, MODEL, OXIDE
Introduction: Methotrexate (MTX) is used to treat cancers, several forms of arthritis and other rheumatic conditions, although MIX may cause pulmonary toxicity related to the production of free oxygen radicals, various cytokines. Infliximab (IB) with its potent effect on tumor necrosis factor-alpha (TNF-alpha) inhibition also inhibits the release of endothelin-1 (ET-1). We aimed to investigate whether IB reduces pulmonary damage induced by an overdose of MIX.