Cyclosporin A therapy on idiopathic thrombotic thrombocytopenic purpura in the relapse setting: two case reports and a review of the literature

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Yılmaz M., Eskazan A. E., Unsal A., Tanınmıs H., Kara E., Cetıner M., ...More

TRANSFUSION, vol.53, no.7, pp.1586-1593, 2013 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 53 Issue: 7
• Publication Date: 2013
• Doi Number: 10.1111/j.1537-2995.2012.03944.x
• Journal Name: TRANSFUSION
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1586-1593
• Open Archive Collection: AVESIS Open Access Collection
• Recep Tayyip Erdoğan University Affiliated: No

Abstract

Background: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease, characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, neurologic disturbances, and renal failure. Plasma therapy has dramatically improved prognosis of TTP, whereas recurrent acute episodes still occur in approximately 40% of patients. Moreover, patients with acquired ADAMTS13 deficiency, which is a significant factor for relapse, may require additional immunosuppressive treatment to get a durable remission.