Is SCUBE1 helpful to predict the arterial thrombotic risk in patients with multiple myeloma: a preliminary study

Akdogan E. , Ayaz T., Kirbas A., Rakici H.

HIPPOKRATIA, vol.23, no.1, pp.21-24, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2019
  • Title of Journal : HIPPOKRATIA
  • Page Numbers: pp.21-24
  • Keywords: Signal peptide-CUB-EGF-like domain-containing protein 1, SCUBE1, multiple myeloma, arterial thrombosis, PROTEIN, COAGULATION, BIOMARKER, DOMAIN


Background: Signal peptide-CUB-EGF-like domain-containing protein I (SCUBE1) is expressed in vascular endothelium and human platelets. SCUBE I levels are increased in acute arterial thrombosis. Multiple myeloma patients are also at increased risk of arterial thrombotic events. This study aimed to measure SCUBE1 levels in newly diagnosed multiple myeloma patients and to define whether SCUBE1 could be a useful marker determining the arterial thrombotic risk.