Is SCUBE1 helpful to predict the arterial thrombotic risk in patients with multiple myeloma: a preliminary study

Akdogan E., Ayaz T., Kirbas A., Rakici H.

HIPPOKRATIA, vol.23, no.1, pp.21-24, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2019
  • Journal Name: HIPPOKRATIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.21-24
  • Keywords: Signal peptide-CUB-EGF-like domain-containing protein 1, SCUBE1, multiple myeloma, arterial thrombosis, PROTEIN, COAGULATION, BIOMARKER, DOMAIN
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Background: Signal peptide-CUB-EGF-like domain-containing protein I (SCUBE1) is expressed in vascular endothelium and human platelets. SCUBE I levels are increased in acute arterial thrombosis. Multiple myeloma patients are also at increased risk of arterial thrombotic events. This study aimed to measure SCUBE1 levels in newly diagnosed multiple myeloma patients and to define whether SCUBE1 could be a useful marker determining the arterial thrombotic risk.