The effect of white tea on serum TNF-alpha/NF-kappa B and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats

Saral, SİNAN; Dokumacioglu, Eda; Mercantepe, TOLGA; Atak, MEHTAP; Cınar, Seda; Saral, ÖZLEM; Yıldız, Lamiye; Iskender, Hatice; Tumkaya, LEVENT

doi:10.1016/j.biopha.2019.108604

The effect of white tea on serum TNF-alpha/NF-kappa B and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats

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Saral S., Dokumacioglu E., Mercantepe T., Atak M., Cınar S., Saral O., ...More

BIOMEDICINE & PHARMACOTHERAPY, vol.112, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 112
Publication Date: 2019
Doi Number: 10.1016/j.biopha.2019.108604
Journal Name: BIOMEDICINE & PHARMACOTHERAPY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: tea, Renal damage, NF-kappa B, TNF-alpha, Caspase-3, Cisplatin, NECROSIS-FACTOR-ALPHA, INDUCED NEPHROTOXICITY, OXIDATIVE STRESS, INDUCED KIDNEY, DNA-DAMAGE, MECHANISMS, INJURY, INTERLEUKIN-6, CONSUMPTION, PROTECTION
Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Objective: Nephrotoxicity is the most important side effect of the antineoplastic drug cisplatin, thereby restricting its use. The aim of this study was to investigate the protective effects of white tea infusions(WT) against renal damage induced by cisplatin(CP) in rats by biochemical and histopathological means.