The effect of white tea on serum TNF-alpha/NF-kappa B and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats


Saral S. , Dokumacioglu E., Mercantepe T. , Atak M. , Cınar S., Saral O. , ...More

BIOMEDICINE & PHARMACOTHERAPY, vol.112, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 112
  • Publication Date: 2019
  • Doi Number: 10.1016/j.biopha.2019.108604
  • Title of Journal : BIOMEDICINE & PHARMACOTHERAPY
  • Keywords: tea, Renal damage, NF-kappa B, TNF-alpha, Caspase-3, Cisplatin, NECROSIS-FACTOR-ALPHA, INDUCED NEPHROTOXICITY, OXIDATIVE STRESS, INDUCED KIDNEY, DNA-DAMAGE, MECHANISMS, INJURY, INTERLEUKIN-6, CONSUMPTION, PROTECTION

Abstract

Objective: Nephrotoxicity is the most important side effect of the antineoplastic drug cisplatin, thereby restricting its use. The aim of this study was to investigate the protective effects of white tea infusions(WT) against renal damage induced by cisplatin(CP) in rats by biochemical and histopathological means.