The effect of white tea on serum TNF-alpha/NF-kappa B and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats

Saral, SİNAN; Dokumacioglu, Eda; Mercantepe, TOLGA; Atak, MEHTAP; Cınar, Seda; Saral, ÖZLEM; Yıldız, Lamiye; Iskender, Hatice; Tumkaya, LEVENT

doi:10.1016/j.biopha.2019.108604

The effect of white tea on serum TNF-alpha/NF-kappa B and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats

Atıf İçin Kopyala

Saral S., Dokumacioglu E., Mercantepe T., Atak M., Cınar S., Saral O., ...Daha Fazla

BIOMEDICINE & PHARMACOTHERAPY, cilt.112, 2019 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 112
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.biopha.2019.108604
Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: tea, Renal damage, NF-kappa B, TNF-alpha, Caspase-3, Cisplatin, NECROSIS-FACTOR-ALPHA, INDUCED NEPHROTOXICITY, OXIDATIVE STRESS, INDUCED KIDNEY, DNA-DAMAGE, MECHANISMS, INJURY, INTERLEUKIN-6, CONSUMPTION, PROTECTION
Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Objective: Nephrotoxicity is the most important side effect of the antineoplastic drug cisplatin, thereby restricting its use. The aim of this study was to investigate the protective effects of white tea infusions(WT) against renal damage induced by cisplatin(CP) in rats by biochemical and histopathological means.