The Importance of Cytokeratin 19 Expression in the Differentiation of Basal Cell Carcinoma and Trichoepithelioma

Bedir R., Şehıtoğlu I., Yurdakul C., Saygın İ., Üstüner P., Dilek N.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, vol.9, no.1, 2015 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.7860/jcdr/2015/10915.5414
  • Journal Name: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, Directory of Open Access Journals
  • Keywords: Differential diagnosis, Follicular germinative cells, Hair buds, Immunohistochemistry, Skin tumour
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Introduction: Basal cell carcinoma (BCC) is the most common skin neoplasm reported in human. On the other hand, trichoepithelioma (TE) is a rare, benign tumour of skin adnexa. The differentiation of BCC and TE may be difficult since their morphological findings are similar. In a few studies, it has been determined that undifferentiated basaloid cells are highly positively stained with cytokeratin 19.