Misophonia is defined as hate of sound. It is characterized with intense emotional reactions like anger, anxiety, or disgust to and avoidance behavior from special sounds such as mouth sounds while eating or chewing gum, nasal sounds like breathing, smelling or blowing or some other sounds done with fingers like playing with a pen, writing or drumming on the table, especially, made by other people. Misophonia has never been present in any of the psychiatric classification systems. Some authors suggest that misophonia should be regarded as a new mental disorder. There is limited information about misophonia. Only few cases of misophonia have been reported. The causes of misophonia, risk factors, the relationship between mental disorders and treatment of misophonia are not fully known. Misophonia is a recently described, poorly understood and neglected condition. Future studies will focus on investigating the epidemiology, phenomenology, neurophysiology, and treatment of the misophonia. Two cases of women who had complaints of misophonia are presented in this study. Principles of diagnosis and treatment in this kind of patients are discussed in our case report.