Prognostic value of Aurora B expression in cancer patients: A meta-analysis
Tumori, cilt.111, sa.3, ss.253-260, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 111 Sayı: 3
- Basım Tarihi: 2025
- Doi Numarası: 10.1177/03008916251343384
- Dergi Adı: Tumori
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS
- Sayfa Sayıları: ss.253-260
- Anahtar Kelimeler: AURKB, Aurora B, Aurora kinase B, cancer, meta-analysis, prognostic role
- Recep Tayyip Erdoğan Üniversitesi Adresli: Evet
Özet
Background: Overexpression of Aurora B is linked to poor prognosis in various malignancies; however, its prognostic role remains debatable. Conducting a meta-analysis is essential to reach a definitive conclusion. Methods: Various databases were searched. Aurora B protein expression was assessed for prognostic significance using pooled hazard ratio (HR) with a 95% confidence interval (CI). Meta-regression and subgroup analysis identified the source of heterogeneity. Results: The study comprised 1384 cancer patients from 10 articles. The result with multivariate data (pooled HR=1.18, 95% CI= 0.71-1.95, p=0.52, I²=83%) and univariate data (pooled HR=1.81, 95% CI=0.92, 3.57, p=0.09, I2=89%) showed that increased Aurora B expression was not linked with poor overall survival (OS). Subgroup analysis showed that sample size, follow-up time, cut-off value, non-Chinese patients, antibody source were not associated with unfavorable OS. Conclusions: Aurora B expression could not be used as a prognostic marker in cancer.