Synthesis and antimicrobial activity evaluation of new norfloxacine-azole hybrids

DEMİRCİ S., DEMİRBAŞ N., Mentese M., Ozdemir S., Karaoglu S. A.

HETEROCYCLIC COMMUNICATIONS, cilt.24, sa.6, ss.317-325, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1515/hc-2018-0070
  • Dergi Adı: HETEROCYCLIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.317-325
  • Anahtar Kelimeler: antimicrobial activity, microwave, norfloxacin, one-pot, 1, 3, 4-oxadiazole, three-component reaction, 1, 2, 4-triazole, MICROWAVE-ASSISTED SYNTHESIS, BIOLOGICAL EVALUATION, ONE-POT, ANTIBACTERIAL, DERIVATIVES, DESIGN, ANTIFUNGAL, ANTICANCER, MOLECULES
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Norfloxacin-azole hybrids 3 and 6a,b were synthesized starting from norfloxacin. The treatment of these compounds with amines as a one-pot three-component reaction produced the corresponding amino derivatives 4a,b, 7a-g and 8a,b in good yields. The conventional and microwave-assisted methods were used with the latter method being more efficient. The structures of the synthesized compounds were characterized by elemental analysis, IR, H-1 NMR, C-13 NMR and MS. All compounds were screened for their antimicrobial activities. Most of them exhibit excellent antibacterial activity but are not active against selected fungi.