Synthesis and antimicrobial activity evaluation of new norfloxacine-azole hybrids

DEMİRCİ S., DEMİRBAŞ N., Mentese M., Ozdemir S., Karaoglu S. A.

HETEROCYCLIC COMMUNICATIONS, vol.24, no.6, pp.317-325, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1515/hc-2018-0070
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.317-325
  • Keywords: antimicrobial activity, microwave, norfloxacin, one-pot, 1, 3, 4-oxadiazole, three-component reaction, 1, 2, 4-triazole, MICROWAVE-ASSISTED SYNTHESIS, BIOLOGICAL EVALUATION, ONE-POT, ANTIBACTERIAL, DERIVATIVES, DESIGN, ANTIFUNGAL, ANTICANCER, MOLECULES
  • Recep Tayyip Erdoğan University Affiliated: Yes


Norfloxacin-azole hybrids 3 and 6a,b were synthesized starting from norfloxacin. The treatment of these compounds with amines as a one-pot three-component reaction produced the corresponding amino derivatives 4a,b, 7a-g and 8a,b in good yields. The conventional and microwave-assisted methods were used with the latter method being more efficient. The structures of the synthesized compounds were characterized by elemental analysis, IR, H-1 NMR, C-13 NMR and MS. All compounds were screened for their antimicrobial activities. Most of them exhibit excellent antibacterial activity but are not active against selected fungi.