Akademik Veri Yönetim Sistemi
The 7th ASEAN Ophthalmology Congress, Bandar-Seri-Begawan, Brunei, 6 - 08 Kasım 2025, ss.60, (Özet Bildiri)
Purpose: This study aimed to evaluate autonomic nerv-ous system (ANS) dysfunction through pupillographic measurements in patients who presented to the neurolo-gy department with persistent chronic headaches fol-lowing the COVID-19 pandemic and were referred to our clinic for assessment of ocular complications. Method: A prospective, controlled cross-sectional de-sign was employed at the Department of Ophthalmolo-gy, involving 20 patients and 19 age- and gender-matched healthy controls. The patient group comprised individuals with no organic pathology detected on neu-roimaging, free of ocular and systemic issues, and re-porting headache symptoms persisting for at least 3 months. Pupillographic assessments encompassed pupil diameters under scotopic, mesopic, and photopic condi-tions, along with dynamic response speeds. Data were analyzed using IBM SPSS Statistics, Version 29.0 (IBM Corp., Armonk, NY, USA) with independent samples t-tests. Results: The patient group exhibited significantly elevated dynamic response speeds com-pared to healthy controls (right pupil [OD]: 0.5329 s⁻¹ vs. 0.2647 s⁻¹, left pupil [OS]: 0.4806 s⁻¹ vs. 0.2980 s⁻¹, p0.05) . Conclusion: The increased dynamic response speed in patients with chronic headaches and no addi-tional complications reflects the inflammatory and neu-rotropic effects of COVID-19 on the ANS, while pupil diameters demonstrate limited discriminatory capacity. The significance of this study lies in unveiling pupillog-raphy's potential as a non-invasive biomarker for diag-nosing post-COVID-19 syndromes and emphasizing the necessity of integrating neuro-ophthalmological assessments into clinical practice.
Keywords: Autonomic nervous system, COVID-19, neuro-ophthalmology, persistent headache, pupillog-raphy