Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in patients with endometrial hyperplasia and endometrial cancer

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URAL U. M., SEHITOGLU I., Tekin Y., SAHIN F. K.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, cilt.41, sa.3, ss.445-448, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/jog.12536
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.445-448
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

AimNeutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet distribution width (PDW) may indicate the systemic inflammatory response associated with various cancers. We aimed to investigate the relationship between NLR, PLR, PDW and endometrial pathologies including hyperplasia and cancer.

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in patients with endometrial hyperplasia and endometrial cancer

By:Ural, UM (Ural, Ulku Mete)[ 1 ] ; Sehitoglu, I (Sehitoglu, Ibrahim)[ 2 ] ; Tekin, YB (Tekin, Yesim Bayoglu)[ 1 ] ; Sahin, FK (Sahin, Figen Kir)[ 1 ]

 

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

 

Volume: 41

 

Issue: 3

 

Pages: 445-448

DOI: 10.1111/jog.12536

Published: MAR 2015

View Journal Information

Abstract

AimNeutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet distribution width (PDW) may indicate the systemic inflammatory response associated with various cancers. We aimed to investigate the relationship between NLR, PLR, PDW and endometrial pathologies including hyperplasia and cancer. 

MethodsIn this study, 472 cases who underwent endometrial biopsy were included. Three groups were constituted with respect to biopsy results: group 1, endometrial cancer patients (n=54); group 2, endometrial hyperplasia patients (n=152); and group 3, patients with normal biopsy results (n=281). White blood cell and platelet counts as well as NLR, PLR and PDW recorded from complete blood counts obtained on the same day of biopsy were compared in the three groups. 

ResultsEndometrial cancer patients were significantly older than the cases in the other two groups (P<0.001). The NLR in group 1 was significantly higher than group 3 (P=0.02). However, there was no difference between the three groups with respect to PLR (P=0.167). PDW was increased in group 1 compared to group 3 (P<0.001). 

ConclusionResults of our study have shown that NLR, PLR and PDW are simple, readily available and robust inflammatory markers that may be used in the management of endometrial pathologies. However, the actual predictive potential of these biomarkers still warrants further trials.

Keywords

Author Keywords:endometrial hyperplasia; endometrial cancer; neutrophil-to-lymphocyte ratio; platelet distribution width; platelet-to-lymphocyte ratio

KeyWords Plus:ELEVATED PREOPERATIVE NEUTROPHIL; RENAL-CELL CARCINOMA; COLORECTAL-CANCER; PROGNOSTIC-FACTOR; NEUTROPHIL/LYMPHOCYTE RATIO; METASTATIC MELANOMA; PERIPHERAL-BLOOD; GASTRIC-CANCER; OVARIAN-CANCER; POOR SURVIVAL