The protective effect of infliximab on cisplatin-induced intestinal tissue toxicity


AYDIN I. , Kalkan Y., OZER E. , Yucel A. F. , PERGEL A. , CURE E., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.18, no.14, pp.2076-2083, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 14
  • Publication Date: 2014
  • Title of Journal : EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Page Numbers: pp.2076-2083
  • Keywords: Cisplatin, Intestinal toxicity, Infliximab, Protective effects, RAT SMALL-INTESTINE, SUPEROXIDE-DISMUTASE, INDUCED APOPTOSIS, ALPHA THERAPY, CHEMOTHERAPY, INDUCTION, INJURY, MODEL

Abstract

OBJECTIVE: Cisplatin (CP) is a popular chemotherapeutic agent. However, high doses of CP may lead to severe side effects to the gastrointestinal system. The aim of this study was to investigate the protective effects of infliximab on small intestine injury induced by high doses of CP.