The protective effect of infliximab on cisplatin-induced intestinal tissue toxicity

AYDIN I., Kalkan Y., OZER E., Yucel A. F., PERGEL A., CURE E., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.18, no.14, pp.2076-2083, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 14
  • Publication Date: 2014
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2076-2083
  • Keywords: Cisplatin, Intestinal toxicity, Infliximab, Protective effects, RAT SMALL-INTESTINE, SUPEROXIDE-DISMUTASE, INDUCED APOPTOSIS, ALPHA THERAPY, CHEMOTHERAPY, INDUCTION, INJURY, MODEL
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

OBJECTIVE: Cisplatin (CP) is a popular chemotherapeutic agent. However, high doses of CP may lead to severe side effects to the gastrointestinal system. The aim of this study was to investigate the protective effects of infliximab on small intestine injury induced by high doses of CP.