The protective effect of infliximab on cisplatin-induced intestinal tissue toxicity

AYDIN I., Kalkan Y., OZER E., Yucel A. F., PERGEL A., CURE E., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.18, sa.14, ss.2076-2083, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 14
  • Basım Tarihi: 2014
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2076-2083
  • Anahtar Kelimeler: Cisplatin, Intestinal toxicity, Infliximab, Protective effects, RAT SMALL-INTESTINE, SUPEROXIDE-DISMUTASE, INDUCED APOPTOSIS, ALPHA THERAPY, CHEMOTHERAPY, INDUCTION, INJURY, MODEL
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Cisplatin (CP) is a popular chemotherapeutic agent. However, high doses of CP may lead to severe side effects to the gastrointestinal system. The aim of this study was to investigate the protective effects of infliximab on small intestine injury induced by high doses of CP.