L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments


Avsar U. Z., Avsar U., AYDIN A., Yayla M., Ozturkkaragoz B., Un H., ...More

NEURAL REGENERATION RESEARCH, vol.9, no.10, pp.1020-1024, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 10
  • Publication Date: 2014
  • Doi Number: 10.4103/1673-5374.133163
  • Journal Name: NEURAL REGENERATION RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1020-1024
  • Keywords: nerve regeneration, peripheral nerve injury, sciatic nerve, L-carnitine, neuroprotection, crush injury, electron microscopy, axon, myelin sheath, neural regeneration, ACETYL-L-CARNITINE, ALZHEIMERS-DISEASE, L-ACETYLCARNITINE, OXIDATIVE STRESS, REGENERATION, ANTIOXIDANT, DYSFUNCTION, CONDUCTION, PROTECTS, PROMOTES
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved significantly. These findings suggest that L-camitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.