Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease

Feng G., Valenti L., Wong V. W., Fouad Y. M., YILMAZ Y., Kim W., ...Daha Fazla

Nature Reviews Gastroenterology and Hepatology, cilt.21, sa.1, ss.46-56, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1038/s41575-023-00846-4
  • Dergi Adı: Nature Reviews Gastroenterology and Hepatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, Food Science & Technology Abstracts, MEDLINE
  • Sayfa Sayıları: ss.46-56
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

Recompensation has gained increasing attention in the field of cirrhosis, particularly in chronic liver disease with a definite aetiology. The current global prevalence of obesity and nonalcoholic fatty liver disease (NAFLD) is increasing, but there is currently a lack of a clear definition for recompensation in NAFLD-related cirrhosis. Here, we provide an up-to-date perspective on the natural history of NAFLD, emphasizing the reversible nature of the disease, summarizing possible mechanisms underlying recompensation in NAFLD, discussing challenges that need to be addressed and outlining future research directions in the field. Recompensation is a promising goal in patients with NAFLD-related cirrhosis, and further studies are needed to explore its underlying mechanisms and uncover its clinical features.