The Relationship Between Sarcopenia and the Systemic Immune-Inflammation Index in a Patient Population Aged 80 and Above
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, cilt.2026, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2026 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1155/ijcp/6666417
- Dergi Adı: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, Directory of Open Access Journals, Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Recep Tayyip Erdoğan Üniversitesi Adresli: Evet
Özet
BackgroundAs the older adult population continues to grow rapidly worldwide, health issues related to aging have become increasingly important in recent years. Sarcopenia, defined as the loss of muscle mass and function associated with aging, significantly impacts the quality of life of older adults.ObjectiveThis study investigated the relationship between the risk of sarcopenia and the Systemic Immune-Inflammation Index (SII) in older adults aged >= 80 years.MethodsThis study involved 214 patients aged >= 80 years who presented to the Rize Recep Tayyip Erdo & gbreve;an University Training and Research Hospital. The risk of sarcopenia was assessed using the Strength, Assistance with Walking, Rising from a Chair, Climbing Stairs, and Falls questionnaire, and laboratory tests were performed to analyze inflammation levels.ResultsThe study revealed significant differences in inflammation parameters among patients at risk of sarcopenia. SII and C-reactive protein/albumin ratio were particularly associated with sarcopenia risk. Age, sex, albumin level, neutrophil count, platelet count, and SII were independent predictors of sarcopenia risk. Receiver operating characteristic analysis showed that the SII was associated with SARC-F-defined sarcopenia risk although its discriminative performance was modest.ConclusionOur findings support a link between systemic inflammation and SARC-F-defined sarcopenia risk in very old adults. Although the discriminative performance of the SII was modest, it may serve as a complementary biomarker in the multidimensional assessment of sarcopenia risk.