Comparison of Radiation-Induced Secondary Malignancy Risk Between Sequential and Simultaneous Integrated Boost for the Treatment of Nasopharyngeal Carcinoma: Intensity-Modulated Radiotherapy versus Volumetric-Modulated Arc Therapy

HACIİSLAMOĞLU E., Cinar Y., Eren M., CANYILMAZ E., GÜRCAN F., Serdar L., ...More

CANCER MANAGEMENT AND RESEARCH, vol.12, pp.2513-2521, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2020
  • Doi Number: 10.2147/cmar.s244901
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.2513-2521
  • Keywords: excess absolute risk, intensity-modulated radiotherapy, organ equivalent dose, secondary cancer risk, volumetric-modulated arc therapy, INDUCED CANCER, NECK-CANCER, IMRT, VMAT, DELIVERY, IMPACT, HEAD
  • Recep Tayyip Erdoğan University Affiliated: Yes


Purpose: This study aimed to compare the secondary cancer risk (SCR) between the sequential boost (SEQ) technique and simultaneous integrated boost (SIB) technique in intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) in patients with nasopharyngeal carcinoma (NPC) using the concepts of organ equivalent dose (OED) and excess absolute risk (EAR).