Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer

TUTAR Y., Özgür A., Tutar E., Tutar L., Pulliero A., Izzotti A.

Biomedicine and Pharmacotherapy, cilt.83, ss.1182-1190, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 83
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.biopha.2016.08.043
  • Dergi Adı: Biomedicine and Pharmacotherapy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1182-1190
  • Anahtar Kelimeler: Biomarker, Lung cancer, miRNA, miRNA therapeutics, Pseudogene
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

Lung cancer is one of the most common mortal cancer types both for men and women. Several different biomarkers have been analyzed to reveal lung cancer prognosis pathways for developing efficient therapeutics and diagnostic agents. microRNAs (miRNAs) and pseudogenes are critical biomarkers in lung cancer and alteration of their expression levels has been identified in each step of lung cancer tumorigenesis. miRNAs and pseudogenes are crucial gene regulators in normal cells as well as in lung cancer cells, and they have both oncogenic and tumor-suppressive roles in lung cancer tumorigenesis. In this study, we have determined the relationship between lung cancer related oncogenes and miRNAs along with pseudogenes in lung cancer, and the results indicate their potential as biological markers for diagnostic and therapeutic purposes.