Bilirubin Levels and Thrombus Burden in Patients With ST-Segment Elevation Myocardial Infarction


HAMUR H., Duman H. , BAKIRCI E. M. , KÜÇÜKSU Z., Demirelli S., Kalkan K., ...More

ANGIOLOGY, vol.67, no.6, pp.565-570, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1177/0003319715603899
  • Title of Journal : ANGIOLOGY
  • Page Numbers: pp.565-570
  • Keywords: bilirubin, myocardial infarction, thrombus burden, PERCUTANEOUS CORONARY INTERVENTION, MICROSOMAL HEME OXYGENASE, DISTAL EMBOLIZATION, PRIMARY ANGIOPLASTY, OXIDATIVE STRESS, REPERFUSION, THERAPY, RISK, FLOW, PROTECTION

Abstract

We investigated whether serum bilirubin level (a marker of heme oxygenase activity) is a predictor of thrombus burden in patients with acute myocardial infarction. Patients (n = 229; male 72.9%; mean age 63 +/- 13.4 years) who were admitted with ST-segment elevation myocardial infarction (STEMI) were enrolled. Patients were divided into 2 groups. Group 1 was defined as low thrombus burden and group 2 was defined as high thrombus burden. Patients with high thrombus burden had higher total bilirubin levels (14.4 [4.3-22.9] vs 7.7 [2.4-20.3] mu mol/L, P .001), (0.84 [0.25-1.34] vs 0.45 [0.14-1.19] mg/dL P .001) and direct bilirubin levels (3.1 [2.1-8.4] vs 1.7 [0.5-6.5] mu mol/L, P .001), (0.18 [0.03-0.49] vs 0.10 [0.03-0.38] mg/dL, P .001). At multivariate analysis, total bilirubin (odds ratio: 1.05, 95% confidence interval: 1.03-1.08, P .001) was the independent predictor of high thrombus burden. In conclusion, total bilirubin level is independently associated with high thrombus burden in patients with STEMI.