Bilirubin Levels and Thrombus Burden in Patients With ST-Segment Elevation Myocardial Infarction

HAMUR H., Duman H., BAKIRCI E. M., KÜÇÜKSU Z., Demirelli S., Kalkan K., ...Daha Fazla

ANGIOLOGY, cilt.67, sa.6, ss.565-570, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1177/0003319715603899
  • Dergi Adı: ANGIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.565-570
  • Anahtar Kelimeler: bilirubin, myocardial infarction, thrombus burden, PERCUTANEOUS CORONARY INTERVENTION, MICROSOMAL HEME OXYGENASE, DISTAL EMBOLIZATION, PRIMARY ANGIOPLASTY, OXIDATIVE STRESS, REPERFUSION, THERAPY, RISK, FLOW, PROTECTION
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

We investigated whether serum bilirubin level (a marker of heme oxygenase activity) is a predictor of thrombus burden in patients with acute myocardial infarction. Patients (n = 229; male 72.9%; mean age 63 +/- 13.4 years) who were admitted with ST-segment elevation myocardial infarction (STEMI) were enrolled. Patients were divided into 2 groups. Group 1 was defined as low thrombus burden and group 2 was defined as high thrombus burden. Patients with high thrombus burden had higher total bilirubin levels (14.4 [4.3-22.9] vs 7.7 [2.4-20.3] mu mol/L, P .001), (0.84 [0.25-1.34] vs 0.45 [0.14-1.19] mg/dL P .001) and direct bilirubin levels (3.1 [2.1-8.4] vs 1.7 [0.5-6.5] mu mol/L, P .001), (0.18 [0.03-0.49] vs 0.10 [0.03-0.38] mg/dL, P .001). At multivariate analysis, total bilirubin (odds ratio: 1.05, 95% confidence interval: 1.03-1.08, P .001) was the independent predictor of high thrombus burden. In conclusion, total bilirubin level is independently associated with high thrombus burden in patients with STEMI.