Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies

Mermer, Arif; BAYRAK, HACER; Sirin, Yakup; Emirik, MUSTAFA; DEMİRBAŞ, NESLİHAN

doi:10.1016/j.molstruc.2019.04.039

Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies

Atıf İçin Kopyala

Mermer A., BAYRAK H., Sirin Y., Emirik M., DEMİRBAŞ N.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1189, ss.279-287, 2019 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 1189
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.molstruc.2019.04.039
Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.279-287
Anahtar Kelimeler: Azole, Phenyl piperazine, beta-Lactam, Antioxidant capacity, Antiurease activity, Molecular docking, ANTIINFLAMMATORY ACTIVITY, RECENT PROGRESS, SCHIFF-BASES, INHIBITORS, DESIGN, 1,3,4-THIADIAZOLE, 1,2,4-TRIAZOLES, ANTIBACTERIAL, ANTIFUNGAL, COMPLEXES
Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

This study reports the synthesis, biological investigation and molecular docking of novel beta-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. The synthesized compounds were evaluated for in vitro antiurease activity and antioxidant capacity. Almost all compounds showed excellent antiurease activity compared to thiourea, standard drug. Also, in silico ADME (absorption, distribution, metabolism, elimination) prediction and molecular docking studies were performed. (C) 2019 Elsevier B.V. All rights reserved.