JOURNAL OF MOLECULAR STRUCTURE, vol.1189, pp.279-287, 2019 (Journal Indexed in SCI)
Article / Article
Title of Journal :
JOURNAL OF MOLECULAR STRUCTURE
Azole, Phenyl piperazine, beta-Lactam, Antioxidant capacity, Antiurease activity, Molecular docking, ANTIINFLAMMATORY ACTIVITY, RECENT PROGRESS, SCHIFF-BASES, INHIBITORS, DESIGN, 1,3,4-THIADIAZOLE, 1,2,4-TRIAZOLES, ANTIBACTERIAL, ANTIFUNGAL, COMPLEXES
This study reports the synthesis, biological investigation and molecular docking of novel beta-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. The synthesized compounds were evaluated for in vitro antiurease activity and antioxidant capacity. Almost all compounds showed excellent antiurease activity compared to thiourea, standard drug. Also, in silico ADME (absorption, distribution, metabolism, elimination) prediction and molecular docking studies were performed. (C) 2019 Elsevier B.V. All rights reserved.