Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies

Mermer A., BAYRAK H., Sirin Y., Emirik M., DEMİRBAŞ N.

JOURNAL OF MOLECULAR STRUCTURE, vol.1189, pp.279-287, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1189
  • Publication Date: 2019
  • Doi Number: 10.1016/j.molstruc.2019.04.039
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.279-287
  • Keywords: Azole, Phenyl piperazine, beta-Lactam, Antioxidant capacity, Antiurease activity, Molecular docking, ANTIINFLAMMATORY ACTIVITY, RECENT PROGRESS, SCHIFF-BASES, INHIBITORS, DESIGN, 1,3,4-THIADIAZOLE, 1,2,4-TRIAZOLES, ANTIBACTERIAL, ANTIFUNGAL, COMPLEXES
  • Recep Tayyip Erdoğan University Affiliated: Yes


This study reports the synthesis, biological investigation and molecular docking of novel beta-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. The synthesized compounds were evaluated for in vitro antiurease activity and antioxidant capacity. Almost all compounds showed excellent antiurease activity compared to thiourea, standard drug. Also, in silico ADME (absorption, distribution, metabolism, elimination) prediction and molecular docking studies were performed. (C) 2019 Elsevier B.V. All rights reserved.