Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in patients with type 2 diabetes

Temizkan S., Deyneli O., Yasar M., Arpa M., GÜNEŞ M., Yazici D., ...More

EUROPEAN JOURNAL OF CLINICAL NUTRITION, vol.69, no.2, pp.162-166, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1038/ejcn.2014.208
  • Journal Name: EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.162-166
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

BACKGROUND/OBJECTIVE: Artificial sweeteners were thought to be metabolically inactive, but after demonstrating that the gustatory mechanism was also localized in the small intestine, suspicions about the metabolic effects of artificial sweeteners have emerged. The objective of this study was to determine the effect of artificial sweeteners (aspartame and sucralose) on blood glucose, insulin, c-peptide and glucagon-like peptide-1 (GLP-1) levels.