Synthesis of Novel Pyrazolines, Their Boron-Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities

KAHRİMAN N., Hasimoglu Z., SERDAROĞLU V., Beris F. Ş., Barut B., YAYLI N.

ARCHIV DER PHARMAZIE, vol.350, no.2, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 350 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1002/ardp.201600285
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Azachalcone, Azaflavone, BOAPPY, BODAF, Pyrazoline, MICROWAVE-ASSISTED SYNTHESIS, BIOLOGICAL EVALUATION, ANTIAMEBIC ACTIVITY, IN-VITRO, DERIVATIVES, TYROSINASE, ANTIDEPRESSANT, EXTRACTS, DESIGN, IDENTIFICATION
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

3,5-disubstituted-2-pyrazoline derivatives (4-6), their boron-fluorine complexes (boron (3-(2'-aminophenyl), 5-(2'-/3'-/4'-pyridyl) pyrazoline, BOAPPY) (7-9) and boron 1,2'-diazaflavone complex (BODAF) (11) were synthesized starting from azachalcones (1-3) to diazaflavone (10), respectively. Biological evaluation of compounds 4-9 and 11 showed remarkable antioxidant, antibacterial, and acetylcholinesterase and tyrosinase enzyme inhibition activities. All newly synthesized compounds 4-9 and 11 showed respectable antibacterial effect with minimum inhibitory concentrations in the range of 4.7-150mg/mL.