Neuroprotective Effects of Olanzapine in <i>N</i>-Methyl-D-Aspartate-Induced Retinal Injury
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, cilt.29, sa.4, ss.427-430, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 4
- Basım Tarihi: 2013
- Doi Numarası: 10.1089/jop.2012.0075
- Dergi Adı: JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.427-430
- Recep Tayyip Erdoğan Üniversitesi Adresli: Evet
Özet
Purpose: The aim of this study was to investigate the neuroprotective effect of olanzapine (OLA), an atypical antipsychotic drug, on N-methyl-D-aspartate (NMDA)-induced retinal injury. Methods: Retinal neuronal ischemia was induced by NMDA in Wistar rats. OLA was administered intraperitoneally in 2 different dosages: 2 and 12 mg/kg. At the end of 2 weeks of OLA treatment, 1 eye of each animal was enucleated for histopathologic examination. We also measured malondialdehyde (MDA) levels in retinal homogenates as a marker of ischemic injury. Results: The retinal ganglion cell (RGC) count was significantly higher in cases where we used OLA 2 mg/kg or OLA 12 mg/kg compared to the control group (P = 0.0032 and P = 0.0005, respectively). We also found that MDA was significantly reduced by OLA 2mg/kg or OLA 12 mg/kg compared to the control group (P = 0.0001 and P = 0.0001, respectively). There was no statistically significant difference between OLA 2 mg/kg or OLA 12mg/kg groups in terms of RGC count and MDA levels (P > 0.05 for all). Conclusion: Our data showed that OLA preserved RGCs from NMDA-induced retinal injury; thus, it may have potential neuroprotective effects.