The effects of dabigatran etexilate on fracture healing in rats An experimental study


KERİMOĞLU S., Onay A., Guvercin Y. , Citlak A., YENİLMEZ E., KERİMOĞLU G.

INDIAN JOURNAL OF ORTHOPAEDICS, cilt.49, ss.357-360, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 49 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4103/0019-5413.156227
  • Dergi Adı: INDIAN JOURNAL OF ORTHOPAEDICS
  • Sayfa Sayıları: ss.357-360

Özet

Background: Deep vein thrombosis leading to pulmonary embolism is one of the major complication after fracture. After a fracture occurs, the coagulation cascade activates thrombin, a protease that finally generates clotting. Dabigatran etexilate reduce clot formation by inhibiting thrombin. Dabigatran etexilate is a widely used drug for thromboprophylaxis. There is no study of the effects of dabigatran etexilate on fracture healing in the literature, so we aimed to evaluate the effects of dabigatran etexilate on fracture healing.