The effects of dabigatran etexilate on fracture healing in rats An experimental study
INDIAN JOURNAL OF ORTHOPAEDICS, vol.49, no.3, pp.357-360, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 49 Issue: 3
- Publication Date: 2015
- Doi Number: 10.4103/0019-5413.156227
- Journal Name: INDIAN JOURNAL OF ORTHOPAEDICS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.357-360
- Recep Tayyip Erdoğan University Affiliated: Yes
Abstract
Background: Deep vein thrombosis leading to pulmonary embolism is one of the major complication after fracture. After a fracture occurs, the coagulation cascade activates thrombin, a protease that finally generates clotting. Dabigatran etexilate reduce clot formation by inhibiting thrombin. Dabigatran etexilate is a widely used drug for thromboprophylaxis. There is no study of the effects of dabigatran etexilate on fracture healing in the literature, so we aimed to evaluate the effects of dabigatran etexilate on fracture healing.