The effects of dabigatran etexilate on fracture healing in rats An experimental study


KERİMOĞLU S., Onay A., Guvercin Y. , Citlak A., YENİLMEZ E., KERİMOĞLU G.

INDIAN JOURNAL OF ORTHOPAEDICS, vol.49, no.3, pp.357-360, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.4103/0019-5413.156227
  • Title of Journal : INDIAN JOURNAL OF ORTHOPAEDICS
  • Page Numbers: pp.357-360

Abstract

Background: Deep vein thrombosis leading to pulmonary embolism is one of the major complication after fracture. After a fracture occurs, the coagulation cascade activates thrombin, a protease that finally generates clotting. Dabigatran etexilate reduce clot formation by inhibiting thrombin. Dabigatran etexilate is a widely used drug for thromboprophylaxis. There is no study of the effects of dabigatran etexilate on fracture healing in the literature, so we aimed to evaluate the effects of dabigatran etexilate on fracture healing.