Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields

RAOOF M., CISNEROS B. T., Guven A., Phounsavath S., CORR S. J., Wilson L. J., ...Daha Fazla

BIOMATERIALS, cilt.34, sa.7, ss.1862-1869, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 7
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.biomaterials.2012.11.033
  • Dergi Adı: BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1862-1869
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

The efficacy of nanoparticle-mediated drug delivery is limited by its pen-vascular sequestration, thus necessitating a strategy to trigger drug release from such intra-tumoral nanocarrier-drug depots. In our efforts to explore remotely-activated nanocarriers, we have developed carbon nanocapsules comprised of an ultra-short carbon nanotube shell (US-tubes) loaded with cisplatin (CDDP@US-tubes) and covered with a Pluronic surfactant wrapping to minimize passive release. We demonstrate here that non-invasive radiofrequency (RF) field activation of the CDDP@US-tubes produces heat that causes Pluronic disruption which triggers cisplatin release in an RF-dependent manner. Furthermore, release-dependent cytotoxicity is demonstrated in human hepatocellular carcinoma cell lines. (C) 2012 Elsevier Ltd. All rights reserved.