Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields


RAOOF M., CISNEROS B. T. , Guven A., Phounsavath S., CORR S. J. , Wilson L. J. , ...Daha Fazla

BIOMATERIALS, cilt.34, ss.1862-1869, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

The efficacy of nanoparticle-mediated drug delivery is limited by its pen-vascular sequestration, thus necessitating a strategy to trigger drug release from such intra-tumoral nanocarrier-drug depots. In our efforts to explore remotely-activated nanocarriers, we have developed carbon nanocapsules comprised of an ultra-short carbon nanotube shell (US-tubes) loaded with cisplatin (CDDP@US-tubes) and covered with a Pluronic surfactant wrapping to minimize passive release. We demonstrate here that non-invasive radiofrequency (RF) field activation of the CDDP@US-tubes produces heat that causes Pluronic disruption which triggers cisplatin release in an RF-dependent manner. Furthermore, release-dependent cytotoxicity is demonstrated in human hepatocellular carcinoma cell lines. (C) 2012 Elsevier Ltd. All rights reserved.