Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields

RAOOF M., CISNEROS B. T., Guven A., Phounsavath S., CORR S. J., Wilson L. J., ...More

BIOMATERIALS, vol.34, no.7, pp.1862-1869, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 7
  • Publication Date: 2013
  • Doi Number: 10.1016/j.biomaterials.2012.11.033
  • Journal Name: BIOMATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1862-1869
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

The efficacy of nanoparticle-mediated drug delivery is limited by its pen-vascular sequestration, thus necessitating a strategy to trigger drug release from such intra-tumoral nanocarrier-drug depots. In our efforts to explore remotely-activated nanocarriers, we have developed carbon nanocapsules comprised of an ultra-short carbon nanotube shell (US-tubes) loaded with cisplatin (CDDP@US-tubes) and covered with a Pluronic surfactant wrapping to minimize passive release. We demonstrate here that non-invasive radiofrequency (RF) field activation of the CDDP@US-tubes produces heat that causes Pluronic disruption which triggers cisplatin release in an RF-dependent manner. Furthermore, release-dependent cytotoxicity is demonstrated in human hepatocellular carcinoma cell lines. (C) 2012 Elsevier Ltd. All rights reserved.