Urease and acetylcholinesterase enzyme inhibitor novel phthalonitrile azo compounds

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Kantar C., Baltaş N., Dereci O. K., Şaşmaz S.

INDIAN JOURNAL OF CHEMISTRY, vol.61, no.11, pp.1188-1193, 2022 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 11
  • Publication Date: 2022
  • Doi Number: 10.56042/ijc.v61i11.68270
  • Journal Name: INDIAN JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Page Numbers: pp.1188-1193
  • Keywords: Phthalonitrile, Azo dyes, Urease, Acetylcholinesterase, Enzyme inhibition, MICROWAVE-ASSISTED SYNTHESIS, HELICOBACTER-PYLORI INFECTION, PHTHALOCYANINES, EUGENOL, AMINOPYRIDINES, DISEASE
  • Open Archive Collection: AVESIS Open Access Collection
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Based on the relationship between Helicobacter pylori and Alzehimer's disease, new azo phthalonitrile compounds containing different amino pyridines have been synthesized. These compounds can inhibit both Urease and Acetylcholinesterase, which are the most important enzymes in the treatment of Helicobacter pylori and Alzehimer's disease, respectively. All compounds have shown better inhibition than standards in the presence of both enzymes. Especialy, azo phthalonitrile compound 4 is more active than other compounds and standards, showed a significant inhibition performance and efficient IC50 values to Urease (20.47 +/- 0.14 mu M) and Acetylcholinesterase (4.73 +/- 0.07 mu M) enzymes. Interestingly, the inhibitory effect of the newly synthesized compounds against to Urease and Acetylcholinesterase is same ranking.