A facile ultrasonic synthesis approach to 3-H-quinazolinethione derivatives and their urease inhibition studies


Çalışkan N., Akyüz G., Menteşe E.

PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.12, no.12, pp.1-6, 2024 (SCI-Expanded)

Abstract

In this study, a new series of 3H-quinazoline-4-thione derivatives were synthesized under ultrasonic irradiation conditions with high yield in  a  short time. The  new compounds were characterized by FT-IR,1H,  and 13C  NMR spectral data. The  antiurease activities of  all  new compounds were tested according to  the  method by  Weatherburn. The  inhibition results with the  3H-quinazoline-4-thione ring  compounds were compared with those of  some previously synthesized 3H-quinazolin-4-ones. More effective results were found for most quinazolinethione compounds. All new synthesized compounds have effective urease inhibition activity. Especially, the compound 2-(4-nitro-benzyl)quinazoline-4(3H)-thione (2i)   has the best inhibition results with IC50 ¼1.6 ± 0.049lg/mL