A facile ultrasonic synthesis approach to 3-<i>H</i>-quinazolinethione derivatives and their urease inhibition studies
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.199, sa.4, ss.293-298, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 199 Sayı: 4
- Basım Tarihi: 2024
- Doi Numarası: 10.1080/10426507.2024.2333471
- Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
- Sayfa Sayıları: ss.293-298
- Anahtar Kelimeler: Quinazoline-4-thione, urease inhibition, ultrasonic irradiation, weatherburn
- Recep Tayyip Erdoğan Üniversitesi Adresli: Evet
Özet
In this study, a new series of 3H-quinazoline-4-thione derivatives were synthesized under ultrasonic irradiation conditions with high yield in a short time. The new compounds were characterized by FT-IR,1H, and 13C NMR spectral data. The antiurease activities of all new compounds were tested according to the method by Weatherburn. The inhibition results with the 3H-quinazoline-4-thione ring compounds were compared with those of some previously synthesized 3H-quinazolin-4-ones. More effective results were found for most quinazolinethione compounds. All new synthesized compounds have effective urease inhibition activity. Especially, the compound 2-(4-nitro-benzyl)quinazoline-4(3H)-thione (2i) has the best inhibition results with IC50 ¼1.6 ± 0.049lg/mL