A facile ultrasonic synthesis approach to 3-<i>H</i>-quinazolinethione derivatives and their urease inhibition studies

Çaliskan N., Akyüz G., Mentese E.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.199, sa.4, ss.293-298, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 199 Sayı: 4
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1080/10426507.2024.2333471
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Sayfa Sayıları: ss.293-298
  • Anahtar Kelimeler: Quinazoline-4-thione, urease inhibition, ultrasonic irradiation, weatherburn
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

In this study, a new series of 3H-quinazoline-4-thione derivatives were synthesized under ultrasonic irradiation conditions with high yield in  a  short time. The  new compounds were characterized by FT-IR,1H,  and 13C  NMR spectral data. The  antiurease activities of  all  new compounds were tested according to  the  method by  Weatherburn. The  inhibition results with the  3H-quinazoline-4-thione ring  compounds were compared with those of  some previously synthesized 3H-quinazolin-4-ones. More effective results were found for most quinazolinethione compounds. All new synthesized compounds have effective urease inhibition activity. Especially, the compound 2-(4-nitro-benzyl)quinazoline-4(3H)-thione (2i)   has the best inhibition results with IC50 ¼1.6 ± 0.049lg/mL