Idiopathic Pulmonary Hemosiderosis with Celiac Disease; Lane-Hamilton Syndrome


Karatas M. , Ozyurt S. , Gumus A. , Kara B. Y. , Sahin U.

JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE, cilt.8, ss.23-25, 2017 (ESCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4328/jcam.4847
  • Dergi Adı: JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE
  • Sayfa Sayıları: ss.23-25

Özet

A 21-year-old male patient presented to our emergency department with the complaints of bloody sputum, respiratory difficulty, lethargy, and fatigue persisting for the previous two days. Fingertip oxygen saturation was 92%, while other vital signs were normal. Bilateral ground-glass opacities were present at thoracic computerized tomography. Laboratory findings were hemoglobin: 8.85g/dL, hematocrit: 28.7%. PT and aPTT values were normal. All rheumatologic laboratory tests were negative. Bronchoalveolar lavage was mildly hemorrhagic and "hemosiderin-laden macrophages" were observed in pathology specimens. The case diagnosed withidiopathic pulmonary hemosiderosis (IPH). Gastroduodenoscopy revealed nodularity in the duodenum, and mucosal biopsies taken from these duedonal regionswere reported as "villous atrophy in mucosal tissues in the duodenum compatible with celiac disease". The only recommended treatment was a gluten-free diet. At follow-up approximately 6 months later, complete remission was achieved. In conclusion, we should be aware, when seeing alveolar hemorrhage related to IPH, that celiac disease can accompany IPH. The concurrence of IPH and celiac disease is known as Lane-Hamilton syndrome. Complete remission in Lane-Hamilton syndrome can be achieved with a gluten-free diet.