Radioprotective effects of alpha 2-adrenergic receptor agonist dexmedetomidine on X-ray irradiation-induced pancreatic islet cell damage

MERCANTEPE F., TÜMKAYA L., MERCANTEPE T., RAKICI S., ÇİFTEL S., ÇİFTEL S.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, vol.396, no.8, pp.1827-1836, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 396 Issue: 8
  • Publication Date: 2023
  • Doi Number: 10.1007/s00210-023-02454-0
  • Journal Name: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1827-1836
  • Keywords: Beta-cell, Dexmedetomidine, Diabetes mellitus, Pancreas, X-ray irradiation, LONG-TERM SURVIVORS, DIABETES-MELLITUS, CHILDHOOD-CANCER, ABDOMINAL RADIATION, RISK, ENDOCRINE, RADIOTHERAPY, THERAPY
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Comprehensive epidemiological analyses conducted in the last 30 years have revealed a link between radiation and DM. We aimed to determine the effects of dexmedetomidine pretreatment on radiation-induced pancreatic islet cell damage. Twenty-four rats were divided into three groups: group 1 (control group), group 2 (only X-ray irradiation group), and group 3 (X-ray irradiation + dexmedetomidine). We observed necrotic cells with vacuoles accompanying loss of cytoplasm in the islets of Langerhans, extensive edematous areas, and vascular congestions in group 2. In group 3, we observed a decrease in necrotic cells in the islets of Langerhans, and edematous areas and vascular congestion was also reduced. We determined a decrease in beta-cells, alpha-cells, and D-cells in the islets of Langerhans in group 2 compared to the control group. In group 3, beta-cells, alpha-cells, and D-cells were elevated compared to group 2. Ionizing radiation may induce DM. Dexmedetomidine appears to exert a radioprotective effect.