Radioprotective effects of alpha 2-adrenergic receptor agonist dexmedetomidine on X-ray irradiation-induced pancreatic islet cell damage

MERCANTEPE F., TÜMKAYA L., MERCANTEPE T., RAKICI S., ÇİFTEL S., ÇİFTEL S.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, cilt.396, sa.8, ss.1827-1836, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 396 Sayı: 8
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00210-023-02454-0
  • Dergi Adı: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1827-1836
  • Anahtar Kelimeler: Beta-cell, Dexmedetomidine, Diabetes mellitus, Pancreas, X-ray irradiation, LONG-TERM SURVIVORS, DIABETES-MELLITUS, CHILDHOOD-CANCER, ABDOMINAL RADIATION, RISK, ENDOCRINE, RADIOTHERAPY, THERAPY
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Comprehensive epidemiological analyses conducted in the last 30 years have revealed a link between radiation and DM. We aimed to determine the effects of dexmedetomidine pretreatment on radiation-induced pancreatic islet cell damage. Twenty-four rats were divided into three groups: group 1 (control group), group 2 (only X-ray irradiation group), and group 3 (X-ray irradiation + dexmedetomidine). We observed necrotic cells with vacuoles accompanying loss of cytoplasm in the islets of Langerhans, extensive edematous areas, and vascular congestions in group 2. In group 3, we observed a decrease in necrotic cells in the islets of Langerhans, and edematous areas and vascular congestion was also reduced. We determined a decrease in beta-cells, alpha-cells, and D-cells in the islets of Langerhans in group 2 compared to the control group. In group 3, beta-cells, alpha-cells, and D-cells were elevated compared to group 2. Ionizing radiation may induce DM. Dexmedetomidine appears to exert a radioprotective effect.