The effect of the substitution of Cu for Ni on the magnetoresistance behaviour and the magnetocaloric properties of the Ni50Mn34In16 alloy has been investigated. The (Ni-Cu)(50)Mn34In16 alloys crystallize in the cubic L2(1) structure in austenite phase. While the M-s temperature is about 160 K for the Ni47.5Cu2.6Mn34.0In15.9 alloy, the martensitic transition is not observed for Ni45.5Cu4.6Mn33.8In16.1 alloy. To estimate the magnetic entropy change of the Ni47.5Cu2.6Mn34.0In15.9 alloy, the magnetization measurements as function of magnetic field are performed by continuous and noncontinuous heating methods. The Ni47.5Cu2.6M34.0In15.9 alloy shows the magnetostructural transition whose irreversible ratio is about 50% at 160 K. The magnetocaloric effect strongly depends on the sample history due to the occurrence of the irreversible magnetostructural transition. For the magnetic field change of 2 T, giant magnetoresistance value is about -68% that is rather big among the similar bulk alloys. (C) 2010 Elsevier B.V. All rights reserved.