In this study, the life of Allâme Muhammed Hüseyin Tabâtabâî, one of the great interpreters of Persian civilization in the contemporary period, and his most important work, al-Mîzân fî Tefsîri'l-Quran, will be discussed. Tabâtabâî was a scholar who made outstanding contributions to the world of science with his commentary (tafsir), sociology, and philosophy works. During his lifetime, he was known for his devotion to science, his struggles with the traditional Iranian scholars, and his handling tradition through intellectualization. He made studies to show all Islamic thought, especially the Iranian scholars, that commentary should be restated by considering the sciences of the age and the people’s needs. The interpretation by Tabâtabâî is one of the most merciless works in bringing Sunni-Shiite wisdom together to discuss the verses and explain them with hadiths and in clarifying the commentary of the Qur'an without sacrificing to the sect fanatic in the Shiite tradition. Tabâtabâî's understanding of commentary, which was centered on guidance and the idea that everyone can understand the Quran, also reveals Tabâtabâî's method of commentary, what he aims with his commentary of the Qur'an, and the whole nature and dimension of his scientific studies. This article aims to cover Tabâtabâî's life and his commentary titled Mîzân with the purpose, sources, nature, and method of writing.