Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats

AYAZOĞLU DEMİR E., MENTEŞE A., Livaoglu A., Alemdar N. T., ALİYAZICIOĞLU Y., DEMİR S.

DRUG AND CHEMICAL TOXICOLOGY, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2023
  • Doi Number: 10.1080/01480545.2023.2172181
  • Journal Name: DRUG AND CHEMICAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Environment Index, Food Science & Technology Abstracts, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Apoptosis, chlorogenic acid, cisplatin, inflammation, ovarian damage, oxidative stress, OXIDATIVE STRESS, INFLAMMATION, APOPTOSIS, DAMAGE, PREVENTION, TOXICITY, TISSUES, LIVER
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and 3 mg/kg) for three days. Oxidative stress (OS), inflammation and apoptosis markers were determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. The levels of OS, inflammation and apoptosis biomarkers increased by CDDP administration (p < 0.05). Treatments with CGA significantly alleviated these markers dose-dependently (p < 0.05). These data reveal that CGA may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue.