Biochemically and histopathologically comparative review of thiamine's and thiamine pyrophosphate's oxidative stress effects generated with methotrexate in rat liver

Demiryilmaz, Ismail; Sener, Ebru; Cetin, Nihal; Altuner, Durdu; Suleyman, Bahadir; ALBAYRAK, Fatih; Akcay, Fatih; Suleyman, Halis

doi:10.12659/msm.883591

Biochemically and histopathologically comparative review of thiamine's and thiamine pyrophosphate's oxidative stress effects generated with methotrexate in rat liver

Atıf İçin Kopyala

Demiryilmaz I., Sener E., Cetin N., Altuner D., Suleyman B., ALBAYRAK F., ...Daha Fazla

MEDICAL SCIENCE MONITOR, cilt.18, sa.12, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18 Sayı: 12
Basım Tarihi: 2012
Doi Numarası: 10.12659/msm.883591
Dergi Adı: MEDICAL SCIENCE MONITOR
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Background: Oxidative liver injury occurring with methotrexate restricts its use in the desired dose. Therefore, whether or not thiamine and thiamine pyrophosphate, whose antioxidant activity is known, have protective effects on oxidative liver injury generated with methotrexate was comparatively researched in rats using biochemical and histopathological approaches.