Effects of nerve growth factor on acetylcholinesterase activity of the proximal stump of the transected sciatic nerve


BAYKAL S., USUL H., ALIYACIOGLU Y., Efe H., DURU S.

NEUROSURGICAL REVIEW, vol.20, no.2, pp.124-127, 1997 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 1997
  • Doi Number: 10.1007/bf01138196
  • Journal Name: NEUROSURGICAL REVIEW
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.124-127

Abstract

28 rats were studied. They were divided into four groups of 7 rats of each: one-day control animals (Group A), seven-day control animals (Group B), one-day nerve growth factor (NGF)-treated animals (Group C) and seven-day NGF-treated animals (Group D). In all animals, the right sciatic nerve was explored and completely transected using micro-scissors under a microscope. In NGF-treated animals, NGF (0.1 mg/kg NGF) was injected subcutaneously. In control animals. there was a statistically significant decrease in AChE activity in the proximal stump of the transected sciatic nerve at 7-day measurements (p < 0.05). In the NGF-treated groups, mean AChE activity in the proximal stump of the transected sciatic nerve was decreased at the 7-day measurement. AChE activity difference between control and NGF-treated groups. measured on the 7th day, are statistically significant (p < 0.01). These results demonstrate the effect of NGF on the cholinergic system.