Synthesis and antimicrobial properties of N-substituted derivatives of (E)-2 ',3 ''-thiazachalcones

Usta A., Taskiran H.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, vol.70, pp.45-50, 2015 (SCI-Expanded) identifier identifier identifier


N-alkyl substituted 2',3 ''-thiazachalcones {3-[(1E)-3-(4-methylthiophene-2-yl)-3-oxoprop-1-en-1-yl]-1-alkyl (C-5-12,C-14) pyridinium bromides} were synthesized by a two-step reaction. The newly synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR, elemental analysis and mass spectral studies. The synthesized compounds were tested for antibacterial activities and found to be more active against Gram-positive as compared to Gram-negative bacteria.