Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD

Gumus A., Altintas N., CINARKA H., Kirbas A., HAZIROGLU M., Karatas M., ...More

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, vol.10, pp.357-365, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2015
  • Doi Number: 10.2147/copd.s77654
  • Journal Name: INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.357-365
  • Keywords: biomarker, chronic obstructive pulmonary disease, inflammation, suPAR, OBSTRUCTIVE PULMONARY-DISEASE, C-REACTIVE PROTEIN, INFLAMMATORY BIOMARKERS, PLASMA-FIBRINOGEN, MORTALITY, LEVEL, SUPAR, RISK
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition, and progresses with acute exacerbations. (AE). During AE, levels of acute phase reactants such as C-reactive protein (CRP) and inflammatory cells in the circulation increase. Soluble urokinase-type plasminogen activator receptor (suPAR) levels increase in acute viral and bacterial infections and in diseases involving chronic inflammation. The purpose of this study was to investigate the effectiveness of suPAR in predicting diagnosis of AE of COPD (AE-COPD) and response to treatment.