Purpose: The purpose of this study is to research the effect of suture button (SB) fixation, a method used at the treatment of ankle syndesmosis injury, which was applied in various angles, pretension force, and levels, on the distal tibiofibular joint (DTFJ) in the mid-stance phase, with the help of three-dimensional finite elements method (FEM)Method: The ankle of a healthy individual was digitally analyzed by a finite element method-based package computer program. Then, anterior inferior tibiofibular ligament (AITFL), interosseous ligament, posterior inferior tibiofibular ligament (PITFL) and deltoid ligament (DL) were cut and force and rotation has been applied to the proximal tibia, resulting in syndesmosis injury. Then, various suture button applications on the injured model have been analyzed. Three parameters have been changed; which were divergence in the axial plane ( 20 degrees, 30 degrees, 40 degrees), distance from the ankle ( 2, 3, 4 cm ), and pretension force ( 20 0, 30 0, 60 0 N )Results: As the result of this study, the rotation, change in the gap between the distal tibia and distal fibula, and the displacements of the fibula in the x and y axes have been obtained, and numerical results were evaluated. As the force increased, rotation, change in the gap between the distal tibia and distal fibula, and the displacements of the fibula decreased. As suture button application rotation increased, change in the gap between the distal tibia and distal fibula, and displacements of the fibula increased. As the distance from the ankle increases and reaches a certain level, the results converge to those of the healthy model; in the proximal, it diverges from healthy results.Conclusion: In the study, it has been shown that abnormal tibiofibular joint movements can be prevented with suture button application, and optimum application parameters (divergence in the axial plane, distance from the ankle, and pretension force) are given for proper reduction.(c) 2022 Elsevier Ltd. All rights reserved.