Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Demiryilmaz, Ismail; Turan, Mehmet; Kisaoglu, Abdullah; GÜLABOĞLU, Mine; Yilmaz, Ismayil; Suleyman, Halis

doi:10.1016/j.pharep.2014.02.015

Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Copy For Citation

Demiryilmaz I., Turan M. I., Kisaoglu A., GÜLABOĞLU M., Yilmaz I., Suleyman H.

PHARMACOLOGICAL REPORTS, vol.66, no.4, pp.647-652, 2014 (SCI-Expanded)

Publication Type: Article / Article
Volume: 66 Issue: 4
Publication Date: 2014
Doi Number: 10.1016/j.pharep.2014.02.015
Journal Name: PHARMACOLOGICAL REPORTS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.647-652
Recep Tayyip Erdoğan University Affiliated: No

Abstract

Background: Nimesulide is a pharmacological agent and selective COX-2 inhibitor. It has anti-inflammatory, analgesic and antipyretic properties. The purpose of this study was to investigate the effect of nimesulide on oxidant/antioxidant, DNA mutation and COX-1/COX-2 activities in rat liver tissue with induced ischemia/reperfusion (I/R).