Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Demiryilmaz I., Turan M. I., Kisaoglu A., GÜLABOĞLU M., Yilmaz I., Suleyman H.

PHARMACOLOGICAL REPORTS, vol.66, no.4, pp.647-652, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1016/j.pharep.2014.02.015
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.647-652
  • Recep Tayyip Erdoğan University Affiliated: No


Background: Nimesulide is a pharmacological agent and selective COX-2 inhibitor. It has anti-inflammatory, analgesic and antipyretic properties. The purpose of this study was to investigate the effect of nimesulide on oxidant/antioxidant, DNA mutation and COX-1/COX-2 activities in rat liver tissue with induced ischemia/reperfusion (I/R).