Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels


Demiryilmaz I., Turan M. I. , Kisaoglu A., GÜLABOĞLU M., Yilmaz I., Suleyman H.

PHARMACOLOGICAL REPORTS, vol.66, no.4, pp.647-652, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1016/j.pharep.2014.02.015
  • Title of Journal : PHARMACOLOGICAL REPORTS
  • Page Numbers: pp.647-652

Abstract

Background: Nimesulide is a pharmacological agent and selective COX-2 inhibitor. It has anti-inflammatory, analgesic and antipyretic properties. The purpose of this study was to investigate the effect of nimesulide on oxidant/antioxidant, DNA mutation and COX-1/COX-2 activities in rat liver tissue with induced ischemia/reperfusion (I/R).