Synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one's aryl Schiff base derivatives and investigation of carbonic anhydrase and cholinesterase (AChE, BuChE) inhibitory properties

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Ozil M., Balaydin H. T., ŞENTÜRK M.

BIOORGANIC CHEMISTRY, vol.86, pp.705-713, 2019 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 86
• Publication Date: 2019
• Doi Number: 10.1016/j.bioorg.2019.02.045
• Journal Name: BIOORGANIC CHEMISTRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.705-713
• Keywords: 1,2,4-Triazole, Schiff base, Benzohydrazide, Carbonic anhydrase, Cholinesterase, Enzyme inhibition, MICROWAVE-ASSISTED SYNTHESIS, SALICYLIC-ACID DERIVATIVES, ALZHEIMERS-DISEASE, BIOLOGICAL EVALUATION, ISOZYMES I, ACETYLCHOLINESTERASE, PHTHALOCYANINES, SULFONAMIDES, BINDING, DESIGN
• Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Carbonic anhydrase enzymes (EC 4.2.1.1, CAs) are metalloenzyme families that catalyze the rapid conversion of H2O and CO2 to HCO3- and H+. CAs are found in different tissues where they participate in various significant biochemical processes such as ion transport, carbon dioxide respiration, ureagenesis, lipogenesis, bone resorption, electrolyte secretion, acid-base balance, and gluconeogenesis. In such processes, many CAs are significant therapeutic targets because of their inhibitory potentials especially in the treatment of some diseases such as edema, glaucoma, obesity, cancer, epilepsy, and osteoporosis. Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are also valuable compounds for different therapeutic applications including Alzheimer's disease. In this work, we report a fast and effective synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one's aryl Schiff base derivatives and also their CA and cholinesterases inhibitory properties. Our findings showed that these Schiff base derivatives, with triazole ring, found as strong CA and cholinesterases inhibitors.