Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destruction

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Ozgur A., Yemis T., Basbulut E., Turgut N. F., Ozdemir D., Akgul G., ...Daha Fazla

JOURNAL OF LARYNGOLOGY AND OTOLOGY, cilt.135, sa.10, ss.879-882, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 135 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1017/s0022215121002103
  • Dergi Adı: JOURNAL OF LARYNGOLOGY AND OTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, MLA - Modern Language Association Database, Veterinary Science Database
  • Sayfa Sayıları: ss.879-882
  • Anahtar Kelimeler: Cholesteatoma, Bone Destruction, Chronic Otitis Media, RESISTANT ACID-PHOSPHATASE, MIDDLE-EAR CHOLESTEATOMA, BREAST-CANCER, SERUM MARKER, RESORPTION, ETIOPATHOGENESIS, METASTASES, RANKL, TRAP, OPG
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

Background Cholesteatoma-related bone destruction is the cause of many complications due to chronic otitis media. This study aimed to evaluate osteoclastic activity in cholesteatoma-related bone destruction using tartrate-resistant acid phosphatase 5b, an enzyme specific to osteoclastic activity. Method Seventy-two patients diagnosed with chronic otitis media were included in this study and were divided into two groups: with and without bone destruction. The blood serum and tissue tartrate-resistant acid phosphatase 5b levels from both groups were compared. Results There were no significant differences in the level of serum enzymes between both groups. However, in tissue samples, tartrate-resistant acid phosphatase 5b levels were significantly lower in the bone destruction group than the group without bone destruction. Conclusion This study determined that the level of tartrate-resistant acid phosphatase 5b, a specific enzyme for osteoclastic activity in cholesteatoma-related bone destruction, is locally decreased. This data suggests that osteoclastic activity may decrease in cholesteatoma-related bone destruction. However, further experimental and clinical studies are required to clarify this highly complex mechanism.