Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destruction

Creative Commons License

Ozgur A., Yemis T., Basbulut E., Turgut N. F., Ozdemir D., Akgul G., ...More

JOURNAL OF LARYNGOLOGY AND OTOLOGY, vol.135, no.10, pp.879-882, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 135 Issue: 10
  • Publication Date: 2021
  • Doi Number: 10.1017/s0022215121002103
  • Journal Name: JOURNAL OF LARYNGOLOGY AND OTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, MLA - Modern Language Association Database, Veterinary Science Database
  • Page Numbers: pp.879-882
  • Keywords: Cholesteatoma, Bone Destruction, Chronic Otitis Media, RESISTANT ACID-PHOSPHATASE, MIDDLE-EAR CHOLESTEATOMA, BREAST-CANCER, SERUM MARKER, RESORPTION, ETIOPATHOGENESIS, METASTASES, RANKL, TRAP, OPG
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

Background Cholesteatoma-related bone destruction is the cause of many complications due to chronic otitis media. This study aimed to evaluate osteoclastic activity in cholesteatoma-related bone destruction using tartrate-resistant acid phosphatase 5b, an enzyme specific to osteoclastic activity. Method Seventy-two patients diagnosed with chronic otitis media were included in this study and were divided into two groups: with and without bone destruction. The blood serum and tissue tartrate-resistant acid phosphatase 5b levels from both groups were compared. Results There were no significant differences in the level of serum enzymes between both groups. However, in tissue samples, tartrate-resistant acid phosphatase 5b levels were significantly lower in the bone destruction group than the group without bone destruction. Conclusion This study determined that the level of tartrate-resistant acid phosphatase 5b, a specific enzyme for osteoclastic activity in cholesteatoma-related bone destruction, is locally decreased. This data suggests that osteoclastic activity may decrease in cholesteatoma-related bone destruction. However, further experimental and clinical studies are required to clarify this highly complex mechanism.