Atherogenic Risk Factors In Female Patients with Overactive Bladder


Uzun H. , Çolak S. , GÜRLEK B.

6. Uluslararası Ürojinekoloji Kongresi, İstanbul, Turkey, 6 - 09 September 2018, pp.0-29

  • Publication Type: Conference Paper / Summary Text
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.0-29

Abstract

Aim: The term overactive bladder (OAB) is used to describe storage symptoms and has been defined as a symptom complex characterised by urinary urgency, with or without urgency incontinence, usually with urinary frequency and nocturia. International population-based studies have reported prevalence rates of OAB around 12% rising to 17% in individuals aged 40 and over. The pathophysiology of OAB has been substantially poorly understood but as our learning of female pelvic health evolves, it is becoming clear that various metabolic, cardiovascular, and endocrine factors play contributory roles. Atherogenic risk factors has been implicated in the aetiology of OAB and is thought to affect bladder function by its stimulating effects on the autonomic nervous system. Therefore, the aim of this study to investigate the relationship of atherogenic parameters including hypertension, dyslipidemia, insulin resistance and visceral obesity with overactive bladder (OAB) in female patients. Methods: Fasting serum levels of insulin, glucose, triglyceride (TG), HDL, LDL, total cholesterol and other cardiovascular parameters including hypertension, visceral obesity and demographic parameters were recorded in 164 female patients. Independent t test was used for statistical analyses. Results: OAB was diagnosed in 86 (52.4%) female patients (group 1) in comparison to 78 (47.6%) female patients without OAB (group 2). All patients had urge urinary incontinence. There was no difference in means of age between the groups, 58.5±12.03 and 52.62±13.27 years, (p< 0.09) respectively. Hypertension was recorded in 67 (78%) patients in group 1 and 48 (61.5%) in group 2, (p<0.015) statistically significant. Twenty eight (32.5%) patients in group 1 and 23 (29.5%) patients in group 2 had a diagnosis of DM (p= 0.5). All Conclusion: Atherogenic risk factors including weight, body mass index, waist circumference, insulin resistance (HOMA-IR), serum TG and HDL levels are associated with OAB in female patients. Weight loss and behavioural modification of lifestyle may be important for preventing and treating OAB. We are needed to further observational studies in a population with atherogenic risk factors to understand the linking mechanism and its potential role in the pathophysiology of the disease.