High dose zoledronic acid increases ischemia-reperfusion damage of the liver

Aydin I., Sehitoglu I., Ozer E., Kalkan Y., TÜMKAYA L., Cure M. C., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.25, no.9, pp.3567-3575, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.26355/eurrev_202105_25839
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.3567-3575
  • Keywords: Zoledronic acid, Ischemia-reperfusion injury, Liver, Caspase, KUPFFER CELLS, INJURY, KIDNEY, METASTASIS, APOPTOSIS, PROTEIN, CANCER
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been reported to exhibit a protective effect against cancers and prevent bone fractures. It also induces apoptosis by increasing proinflammatory cytokines and oxidative stress. Oxidative stress increases significantly during ischemia-reperfusion (IR) injury. The liver is highly sensitive to IR injury. In this study, we aim to investigate whether high-dose ZA treatment affects the liver during IR.