High dose zoledronic acid increases ischemia-reperfusion damage of the liver

Aydin I., Sehitoglu I., Ozer E., Kalkan Y., TÜMKAYA L., Cure M. C., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.25, sa.9, ss.3567-3575, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.26355/eurrev_202105_25839
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.3567-3575
  • Anahtar Kelimeler: Zoledronic acid, Ischemia-reperfusion injury, Liver, Caspase, KUPFFER CELLS, INJURY, KIDNEY, METASTASIS, APOPTOSIS, PROTEIN, CANCER
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been reported to exhibit a protective effect against cancers and prevent bone fractures. It also induces apoptosis by increasing proinflammatory cytokines and oxidative stress. Oxidative stress increases significantly during ischemia-reperfusion (IR) injury. The liver is highly sensitive to IR injury. In this study, we aim to investigate whether high-dose ZA treatment affects the liver during IR.