High dose zoledronic acid increases ischemia-reperfusion damage of the liver


Aydin I. , Sehitoglu I., Ozer E., Kalkan Y., TÜMKAYA L. , Cure M. C. , ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.25, sa.9, ss.3567-3575, 2021 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Konu: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.26355/eurrev_202105_25839
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Sayfa Sayıları: ss.3567-3575

Özet

OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been reported to exhibit a protective effect against cancers and prevent bone fractures. It also induces apoptosis by increasing proinflammatory cytokines and oxidative stress. Oxidative stress increases significantly during ischemia-reperfusion (IR) injury. The liver is highly sensitive to IR injury. In this study, we aim to investigate whether high-dose ZA treatment affects the liver during IR.