Akademik Veri Yönetim Sistemi
Revista Brasileira de Anestesiologia, cilt.63, sa.2, ss.183-187, 2013 (SCI-Expanded)
Background and Objectives: This study investigates analgesic and nociceptive effects of adding dexmedetomidine to bupivacaine neuraxial anesthesia through Tail-flick (TF) and Hot-plate (HP) tests and the pathohistological changes on spinal nerves and nerve roots through light microscopy. Methods: Forty anesthetized, male Sprague-Dawley rats were intrathecally catheterized. Basal values of TF and HP tests were measured before and after catheterization. Thirty-six successfully catheterized rats were assigned to four groups. Group B received 10μg bupivacaine, Group BD3 received 10μg bupivacaine + 3μg dexmedetomidine, Group BD10 received 10μg bupivacaine + 10μg dexmedetomidine and Control group received 10μL volume of artifi cial cerebrospinal fluid. TF and HP tests were performed between the 5th and 300th minutes of drug administration. Twenty-four hours after administration of drugs, rats were sacrifi ced and spinal cord and nerve roots were removed for pathological investigation. Results: Baseline values of the TF and HP tests were not statistically different among the groups (6.8±0.15 s). TF and HP latencies in the Control group did not change signifi cantly during the study. TF and HP test results showed that adding 3 and 10. μg dexmedetomidine caused a dosedependent increase in duration and amplitude of analgesic and nociceptive effect of bupivacaine (TF: 37.52±1.08%, 57.86±1.16% respectively, HP: 44.24±1.15%, 68.43±1.24% respectively). Conclusions: There were no apparent pathohistological changes at least 24 hours after the intrathecal administration of a single dose of dexmedetomidine 3. μg and 10. μg. Dexmedetomidine added to bupivacaine for spinal block improves analgesia and prolongs block duration. © 2013 Elsevier Editora Ltda.