Atıf İçin Kopyala
Özyıldız A. G., Özyıldız A., Çetin M.
Eskisehir Medical Journal, Eskisehir City Hospital, cilt.4, sa.1, ss.17-22, 2023 (Hakemli Dergi)
Özet
Introduction: His-ventricle (H-V) interval is one of the basic
measurements of the electrophysiology study (EPS), reflecting
conduction time through the His-Purkinje system. Fibrosis and fatty
infiltration take a role in the development of H-V interval prolongation.
Recent studies claimed that fibrosis in the conduction system could
be triggered by oxidative stress. Gamma-glutamyl transferase (GGT)
is a non-specific marker of oxidative stress and can be practically
evaluated in the clinic. The study aimed to investigate the association
of H-V interval prolongation and GGT level.
Methods: The study included 94 consecutive patients (58 women)
who underwent clinically indicated EPS with the diagnosis of
supraventricular tachycardia. Gamma-glutamyl transferase level
was measured with routine laboratory tests before the procedure.
Atrial-His, H-V intervals and basal cycle length were measured by
performing the standard EPS protocol to patients.
Results: Patient’s mean age was 47.9±15.8 years. Participants were
analyzed in two groups according to the duration of the H-V interval:
≤ 55 ms (n=66) and >55 ms (n=28). Body-mass index (BMI) (OR
1.153, 95% CI 1.029-1.292, p=0.014) and GGT levels (OR 1.060,
95% CI 1.013-1.108, p=0.012) were independently associated with
H-V interval prolongation in multivariate logistic regression analysis.
Conclusion: Gamma-glutamyl transferase and BMI are independently
associated with H-V interval prolongation. The relationship of GGT
with H-V interval, which extensive studies should confirm, can be
a practical aid in the follow-up of patients with infra-His conduction
defects.