Evaluation of periostin, fibronectin and tenascin-C in patients chronic otitis media with cholesteatoma

Birinci M., Terzi S., Demir E., ÇELİKER M., Okcu O., ARPA M., ...Daha Fazla

EGYPTIAN JOURNAL OF OTOLARYNGOLOGY, cilt.38, sa.1, 2022 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1186/s43163-022-00220-2
  • Dergi Adı: EGYPTIAN JOURNAL OF OTOLARYNGOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Anahtar Kelimeler: Chronic otitis media, Cholesteatoma, Periostin, Fibronectin, Tenascin-C, MIDDLE-EAR CHOLESTEATOMA, GROWTH-FACTOR, EXPRESSION, PROTEIN, BIOMARKER, MEMBRANE
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Background: Although many studies have investigated the mechanisms of cholesteatoma formation, its pathogenesis remains unclear. The aim of this study was to evaluate the levels of periostin, fibronectin and tenascin-C, which are involved in many mechanisms, such as cell adhesion, cell differentiation, inflammation, fibrosis, angiogenesis and cell proliferation, in patients with chronic otitis media (COM). A total of 80 participants, 65 COM patients undergoing surgery and 15 healthcare personnel volunteers serving as controls, were included in this study. The participants were divided into four groups: cholesteatoma, granulation, avivation and control group. The serum periostin, fibronectin and tenascin-C levels of all participants were determined biochemically. Histopathological evaluation of tissue samples and 20 skin samples used as controls was performed by immunohistochemistry.