Evaluation of periostin, fibronectin and tenascin-C in patients chronic otitis media with cholesteatoma


Birinci M., Terzi S. , Demir E., ÇELİKER M. , Okcu O., ARPA M. , ...More

EGYPTIAN JOURNAL OF OTOLARYNGOLOGY, vol.38, no.1, 2022 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1186/s43163-022-00220-2
  • Title of Journal : EGYPTIAN JOURNAL OF OTOLARYNGOLOGY
  • Keywords: Chronic otitis media, Cholesteatoma, Periostin, Fibronectin, Tenascin-C, MIDDLE-EAR CHOLESTEATOMA, GROWTH-FACTOR, EXPRESSION, PROTEIN, BIOMARKER, MEMBRANE

Abstract

Background: Although many studies have investigated the mechanisms of cholesteatoma formation, its pathogenesis remains unclear. The aim of this study was to evaluate the levels of periostin, fibronectin and tenascin-C, which are involved in many mechanisms, such as cell adhesion, cell differentiation, inflammation, fibrosis, angiogenesis and cell proliferation, in patients with chronic otitis media (COM). A total of 80 participants, 65 COM patients undergoing surgery and 15 healthcare personnel volunteers serving as controls, were included in this study. The participants were divided into four groups: cholesteatoma, granulation, avivation and control group. The serum periostin, fibronectin and tenascin-C levels of all participants were determined biochemically. Histopathological evaluation of tissue samples and 20 skin samples used as controls was performed by immunohistochemistry.